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For all other article types, kindly ensure that they are included so that your article can be published according to journal style. Please provide five keywords. Keywords should be taken from those recommended by the US National Library of Medicine's Medical Subject Headings MeSH browser list at se double spacing throughout, including title page, abstract, text, acknowledgements, references, footnotes, tables and legends for illustrations. Begin each of the following sections on separate pages: title page, abstract and key words, text, acknowledgements, references, footnotes, figure legends, and individual tables. Number pages consecutively, beginning with the title page. TextThe text of the original research manuscript should be divided into the following sections with headings: Introduction, Methods, Results, Discussion. Longer articles may be further divided with appropriate subheadings. Review Articles should be suitably divided with appropriate subheadings. As papers are double blind peer reviewed, the main text file should not include any information that might identify the authors. The journal uses British/US spelling; however, authors may submit using either option, as spelling of accepted papers is converted during the production process. Trade Names: Chemical substances should be referred to by the generic name only. Trade names should not be used. Drugs should be referred to by their generic names. If proprietary drugs have been used in the study, refer to these by their generic name, mentioning the proprietary name and the name and location of the manufacturer in parentheses. IntroductionState the purpose of the article. Summarize the rationale for the study, giving only pertinent references, and do not review the subject extensively. Do not include data or conclusions from the work to be reported. Materials and methodsIdentify the methods, apparatus include manufacturer's name and address in parentheses, and procedures in sufficient detail to allow other workers to reproduce the results. Give references to established methods; provide references and brief descriptions for methods that have been published but are not well known; and describe in greater detail new or substantially modified methods. Identify precisely all drugs and chemicals used, including generic names, doses, and routes of administration. If a method or tool is introduced in the study, including software, questionnaires, and scales, the author should state the license this is available under and any requirement for permission for use. If an existing method or tool is used in the research, the authors are responsible for checking the license and obtaining the permission. If permission was required, a statement confirming permission should be included in the Methods and Materials section. StatisticsStatistical methods must be described in sufficient detail to enable a knowledgeable reader with access to the original data to verify the reported results. Whenever possible, quantify findings and present then with appropriate indicators of measurement error or uncertainty. Statistical probability p should be reported in tables, figures, and figure legends at only one of the following levels pResultsPresent the results in a logical sequels in the tables and illustrations.

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